Ole Gunnar Solskjaer's side, who had won their last ten away games in the Premier League, stay third on 27 points, a point behind second-placed Leicester.
Mohamed Salah hit a hat-trick as Liverpool humiliated Manchester United, romping to a stunning 5-0 victory at Old Trafford in the Premier League on Sunday that leaves Ole Gunnar Solskjaer's future in serious doubt.
Manchester United completed their first home and away Premier League double over Manchester City since the Alex Ferguson era with a 2-0 victory at Old Trafford on Sunday.. Earlier, two goals in each half from a rampant Chelsea earned them a 4-0 victory over Carlo Ancelotti's Everton, cementing their place in the Premier League's top four.
Given the improvements at Chelsea and Arsenal, it will still be a significant achievement for United to secure a top four finish and in the Champions League, a decent run in the knockout stages would also be a sign of progress.
Arsenal's best chance to equalise came from a Granit Xhaka free kick which looked destined for the top corner until the Gunner's former keeper Emiliano Martinez at full stretch pushed it around the post with a fingertip save.
As the Premier League resumes following the international break all eyes will be on Cristiano Ronaldo's homecoming party at Old Trafford on Saturday, with the Portuguese international set to resume his Manchester United career after 12 years away.
Chelsea manager Frank Lampard was delighted with the discipline of his team, who ended United's 19-game unbeaten run.
Images from the English Premier League matches played on Saturday.
Manchester City were confirmed as English Premier League champions for the fifth time in six seasons on Saturday without even having to kick a ball.
Images from Tuesday's action in the English Premier League
Portugal captain Cristiano Ronaldo scored his 99th international goal as the defending champions edged past Luxembourg 2-0
Brazil are pre-tournament favourites to win a record-extending sixth title.
Should Manchester United win their next two games, the gap will be cut to four points and while only a collapse of astonishing proportions would deny Manchester City the title.
A summary of Sunday's action in the Premier League.
Images from Sunday's action in the Premier League.
Arsenal ended their seven match winless run in the Premier League with a surprise 3-1 London derby victory over Chelsea at the Emirates Stadium on Saturday while Manchester United were held to a 2-2 draw at Leicester City.
Inter Milan midfielder Christian Eriksen scored his first goal for the club since last month's move from Tottenham Hotspur to set up a 2-0 win at Ludogorets Razgrad in their Europa League last 32, first leg on Thursday. Getafe pulled off a surprise 2-0 home win over last year's Champions League semi-finalists Ajax Amsterdam, while Manchester United were held 1-1 at Club Brugge in wet and windy conditions. Wolverhampton Wanderers' Diogo Jota scored a second successive hat-trick in the competition to lead his side to a 4-0 victory over Espanyol and Arsenal won 1-0 at Olympiakos Piraeus with a late Alexandre Lacazette goal.
Manchester United's Bruno Fernandes fired home a late penalty to rescue a point for the visitors in a lively 1-1 draw at Tottenham Hotspur in the Premier League on Friday.
Bruno Fernandes and Edinson Cavani scored twice each as Manchester United took a giant step towards the Europa League final with a 6-2 drubbing of AS Roma in their semi-final first leg at Old Trafford on Thursday.
Everton and Manchester United drew 1-1 at Goodison Park in the Premier League on Sunday in an enthralling game which ended with late VAR drama.
Centre forward Eder, who scored the winning goal in the Euro 2016 final against France, was among 10 players from that squad omitted from Santos's list. Other unlucky players included midfielders Andre Gomes and Renato Sanches, forward Nani and defender Eliseu.
After a tense encounter finished 1-1 following extra time, Villareal's Rulli stepped up after every on-field player scored their spot kicks and he comfortably beat Spaniard De Gea
Roberto Firmino scored twice as Liverpool boosted their hopes of Champions League football next season
Images from Saturday's action in the English Premier League.
Tottenham Hotspur missed the chance to move up to provisional fourth place in the Premier League after relegation-threatened Newcastle United held them to a 2-2 draw with a late equaliser from substitute Joe Willock at St James' Park on Sunday. Images from EPL matches played on Sunday.
Irish Prime Minister Michael Martin was among the first to tweet his reaction.
Images from Thursday's action in the Europa League Europa League - Round of 16 Second Leg - matches.
Napoli suffered their first defeat of the season on Sunday when they lost 1-0 at lowly Atalanta while Serie A leaders Juventus surged on with a 3-0 win at Empoli, helped by a Gonzalo Higuain brace.
Manchester United returned to winning ways in ruthlessly emphatic fashion
Images from Sunday's action in the Premier League.
IMAGES from the English Premier League matches played on Saturday
Brighton & Hove Albion scored three times in the second half to fight back from two goals down and beat Manchester City
IMAGES from the Premier League matches played on Sunday.
Leicester City reached the FA Cup final for the first time in more than 50 years
Manchester City took a major step towards retaining their Premier League title with a 1-0 win over second-placed Chelsea on Saturday, opening up a 13-point lead at the top of the table for Pep Guardiola's side.
Manchester United's miserable season continued with a 3-2 home defeat by Galatasaray.
IMAGES from the English Premier League matches played on Sunday.
Roundup of the Champions League matches played on Wednesday night
Headed goals from Anthony Martial and captain Harry Maguire earned Manchester United a hard-fought 2-0 win at toothless Chelsea on Monday amid more VAR controversy, putting them back in the hunt for a top-four Premier League finish. The VAR system made the headlines once again after two Chelsea efforts were ruled out and England international Maguire escaped sanction for a kick out at Michy Batshuayi.
Images from Saturday's matches in the Premier League.
